Inter on the verge of Serie A triumph while AC Milan take on Juventus
Cristian Chivus squad are ahead of both the current title holders Napoli and runners up Milan by 12 points, with just five games left in the campaign.
They could find out by the end of Friday if they secure a 21st Scudetto for Inter, as Napoli entertain struggling Cremonese at home.
Should Napoli fail to win, Inter will head to Torino in Turin, where victory might clinch the championship with four fixtures still to play.
However, they would need to hold off until the outcome of Milans big game against Juventus at the San Siro, which matters greatly for both sides Champions League aspirations.
Claiming the title so early would mark an impressive turnaround, since before the latest international pause, Inter seemed unsteady and Napoli along with Milan appeared poised to overtake them.
Yet, collecting all nine possible points and netting 12 goals across the three games since competitive action resumed has swung momentum back towards Inter, making the titles destination a question of when, not if.
Inter enter this round eyeing a domestic double following an exciting victory against Como that guaranteed their spot in the Italian Cup final next month against Lazio.
Even without considering results from Napoli or Milan, Inter realise that picking up four more points from their leftover matches will confirm the league win.
Milan are in a peculiar spot where they might unintentionally gift the trophy to their city opponents, though it pales compared to two years back when they handed it to Inter via a defeat in the derby.
Nevertheless, Massimiliano Algrris team are nearly assured of Champions League football again, thanks to their eight point buffer over fifth placed Como.
Milan ought to end in the top four regardless of a loss on Sunday, whereas Joves position looks shakier in fourth, holding a five point advantage over Como in fifth and Roma in sixth.
Como, who squandered a two goal lead before Inter eliminated them from the Cup, face a tough challenge away at a revitalised Genoa, who might lock in their survival this round.
Key player to follow: Adrien Rabiot
The French midfielder Rabiot confronts his former club on Sunday and will spearhead Milans push against Juve, supported by Luka Modric.
Rabiot has justified Algrris trust with six goals and four assists across 25 league outings, his most recent effort at Verona highlighting his strong surges and clinical finishing.
This 31 year old joined Milan largely on Algrris recommendation, after Marseille let him go in August amid a heated clash with squad mate Jonathan Rowe.
Rabiot was central to Joves previous Serie A success in 2020, staying for four additional years with the Turin outfit before his switch to Marseille.